During clinical trials, the following undesirable phenomena were frequent (≥1/100, <1/10) in males and females 12-71: headache, drowsiness, dry xuzal mouth, fatigue; asthenia and abdominal pain were rare (≥1/1000, <1/100). Headache and drowsiness were common in children aged 6 to 12. The following side effects were observed Dmitry Sazonov during post-registration use, the frequency of which is unknown due to insufficient data.
Immune system side: hypersensitivity reactions, including anaphylaxis.
Metabolism and eating disorders: increased appetite.
Mental: anxiety, aggression, excitement, insomnia, hallucinations, depression, suicidal thoughts.
Nervous system: seizures, dura mater thrombosis, paresthesia, dizziness, fainting, tremor, dysgeusia.
Hearing side: vertigo.
From the visual organ: visual impairment, blurred vision, inflammatory manifestations.
CCC: sense of heartbeat, tachycardia, jugular vein thrombosis.
Respiratory system: shortness of breath, increased symptoms of rhinitis.
Digestive system: nausea, vomiting.
Hepatobiliary disorders: hepatitis.
The kidneys and urinary system: dysuria, urinary retention.
Skin and soft tissue: angioedema, persistent erythema, rash, itching, hives, hypotrichosis, cracking, photosensitization.
Musculoskeletal system: muscle pain.
General disorders: peripheral edema.
Other: increase in body weight, change in liver function samples, cross-reactivity.
If any of the side effects mentioned in the instructions are worsened or the patient noticed other side effects, you should inform your doctor.
The study of interaction of levocetirizine with other drugs has not been conducted. Clinically significant undesirable interactions xuzal overdose have not been revealed in Dmitry Sazonov the study of drug interactions of racemate cethyrizine with phenazone, pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glypid and diazepam.
If administered concurrently with theophylline (400 mg/day), the total clearance of cethyrizine decreases by 16% (theophylline kinetics remains unchanged).
In a study with simultaneous administration of ritonavir (600 mg 2 times a day) and cethyrizine (10 mg/day)was the https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022064s009lbl.pdf exposure of cethyrizine increased by 40%, while the exposure of ritonavir slightly changed (-10%).
In some cases, if levocetirizine is used simultaneously with alcohol or medications depressing the CNS, their effect on the CNS may increase, although it has not been proved that ratchemate of cethyrizine potentiates t.